NLS (PKKKRKV) (TFA)

NLS (PKKKRKV) TFA is the TFA form of NLS (PKKKRKV) (HY-P1876) . NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].

Product Specifications

UNSPSC

12352209

Target

DNA/RNA Synthesis

Type

Peptides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nls-pkkkrkv-tfa.html

Solubility

10 mM in DMSO

Smiles

CC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]1NCCC1)=O)CCCCN)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCCN)=O)C(O)=O)C.O=C(O)C(F)(F)F

Molecular Formula

C42H79F3N14O10

Molecular Weight

997.16

References & Citations

[1]Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96 (1) :91-6.|[2]Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound‑targeted microbubble destruction‑mediated gene transfection. Mol Med Rep. 2017 Jul;16 (1) :565-572.