FLT3-IN-3
FLT3-IN-3 is a potent FLT3 inhibitor with IC50s of 13 and 8 nM for FLT3 WT and FLT3 D835Y, respectively.
Product Specifications
CAS Number
2229050-90-0
UNSPSC
12352005
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/FLT3-IN-3.html
Purity
99.95
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
N[C@H](CC1)CC[C@@H]1NC2=NC3=C(N=CN3C4CCCC4)C(NC5=CC=C(CN6CCOCC6)C=C5)=N2
Molecular Formula
C27H38N8O
Molecular Weight
490.64
References & Citations
[1]Gucký T, et al. Discovery of N2- (4-Amino-cyclohexyl) -9-cyclopentyl- N6- (4-morpholin-4-ylmethyl-phenyl) - 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations. J Med Chem. 2018 May 10;61 (9) :3855-3869.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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