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FLT3-IN-3

FLT3-IN-3 is a potent FLT3 inhibitor with IC50s of 13 and 8 nM for FLT3 WT and FLT3 D835Y, respectively.

Product Specifications

CAS Number

2229050-90-0

UNSPSC

12352005

Target

FLT3

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/FLT3-IN-3.html

Purity

99.95

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

N[C@H](CC1)CC[C@@H]1NC2=NC3=C(N=CN3C4CCCC4)C(NC5=CC=C(CN6CCOCC6)C=C5)=N2

Molecular Formula

C27H38N8O

Molecular Weight

490.64

References & Citations

[1]Gucký T, et al. Discovery of N2- (4-Amino-cyclohexyl) -9-cyclopentyl- N6- (4-morpholin-4-ylmethyl-phenyl) - 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations. J Med Chem. 2018 May 10;61 (9) :3855-3869.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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