Alpha-2-macroglobulin, Human (sf9, His)

Alpha-2-macroglobulin Protein, a protease inhibitor and cytokine transporter, belongs to the MEROPS proteinase inhibitor family I39, clan IL. A2M acts on all classes of endoproteases and could potentially be used to slow or halt PTOA by neutralizing catabolic cascades in affected cartilage. A2M can enter into cells and bind to numerous cytokines. It inhibits inflammatory mediators of chondrocytes by blocking IL-1尾/NF-魏B pathway. Alpha-2-macroglobulin Protein, Human (sf9, His) is the recombinant human-derived Alpha-2-macroglobulin protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Alpha-2-macroglobulin Protein, Human (sf9, His) is 1451 a.a., with molecular weight of 160-170 kDa.

SVSGKPQYMV LVPSLLHTET TEKGCVLLSY LNETVTVSAS LESVRGNRS LFTDLEAEND VLHCVAFAVP KSSSNEEVMF LTVQVKGPTQ EFKKRTTVMV KNEDSLVFVQ TDKSIYKPG QTVKFRVVSM DENFHPLNEL IPLVYIQDPK GNRIAQWQSF QLEGGLKQFS FPLSSEPFQG SYKVVVQKK SGGRTEHPFT VEEFVLPKFE VQVTVPKIIT ILEEEMNVSV CGLYTYGKPV PGHVTVSICR KYSDASDCHG EDSQAFCEK FSGQLNSHGC FYQQVKTKVF QLKRKEYEMK LHTEAQIQEE GTVVELTGRQ SSEITRTITK LSFVKVDSH FRQGIPFFGQ VRLVDGKGVP IPNKVIFIRG NEANYYSNAT TDEHGLVQFS INTTNVMGTS LTVRVNYKD RSPCYGYQWV SEEHEEAHHT AYLVFSPSKS FVHLEPMSHE LPCGHTQTVQ AHYILNGGTL LGLKKLSFY YLIMAKGGIV RTGTHGLLVK QEDMKGHFSI SIPVKSDIAP VARLLIYAVL PTGDVIGDSA KYDVENCLA NKVDLSFSPS QSLPASHAHL RVTAAPQSVC ALRAVDQSVL LMKPDAELSA SSVYNLLPEK DLTGFPGPL NDQDDEDCIN RHNVYINGIT YTPVSSTNEK DMYSFLEDMG LKAFTNSKIR KPKMCPQLQQ YEMHGPEGL RVGFYESDVM GRGHARLVHV EEPHTETVRK YFPETWIWDL VVVNSAGVAE VGVTVPDTIT EWKAGAFCL SEDAGLGISS TASLRAFQPF FVELTMPYSV IRGEAFTLKA TVLNYLPKCI RVSVQLEASP AFLAVPVEK EQAPHCICAN GRQTVSWAVT PKSLGNVNFT VSAEALESQE LCGTEVPSVP EHGRKDTVIK PLLVEPEGL EKETTFNSLL CPSGGEVSEE LSLKLPPNVV EESARASVSV LGDILGSAMQ NTQNLLQMPY GCGEQNMVLF APNIYVLDY LNETQQLTPE IKSKAIGYLN TGYQRQLNYK HYDGSYSTFG ERYGRNQGNT WLTAFVLKTF AQARAYIFI DEAHITQALI WLSQRQKDNG CFRSSGSLLN NAIKGGVEDE VTLSAYITIA LLEIPLTVTH PVVRNALFC LESAWKTAQE GDHGSHVYTK ALLAYAFALA GNQDKRKEVL KSLNEEAVKK DNSVHWERPQ KPKAPVGHF YEPQAPSAEV EMTSYVLLAY LTAQPAPTSE DLTSATNIVK WITKQQNAQG GFSSTQDTVV ALHALSKYG AATFTRTGKA AQVTIQSSGT FSSKFQVDNN NRLLLQQVSL PELPGEYSMK VTGEGCVYLQ TSLKYNILP EKEEFPFALG VQTLPQTCDE PKAHTSFQIS LSVSYTGSRS ASNMAIVDVK MVSGFIPLKP TVKMLERSN HVSRTEVSSN HVLIYLDKVS NQTLSLFFTV LQDVPVRDLK PAIVKVYDYY ETDEFAIAEY NAPCSKDLG NA