10-Gingerol

10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC50 value of 10.47 μM against DPPH radical, an IC50 value of 1.68 μM against superoxide radical and an IC50 value of 1.35 μM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol is promising for research of ulcerative colitis[1][2][3][4][5].

Product Specifications

CAS Number

[23513-15-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Akt; AMPK; Apoptosis; Interleukin Related; PI3K; Reactive Oxygen Species (ROS) ; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/10-gingerol.html

Purity

99.34

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCCC[C@H](O)CC(CCC1=CC=C(O)C(OC)=C1)=O

Molecular Formula

C21H34O4

Molecular Weight

350.49

Precautions

H315, H319, H335

References & Citations

[1]Dugasani S, et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol. 2010 Feb 3;127 (2) :515-20.|[2]Almada da Silva J, et al. Purification and differential biological effects of ginger-derived substances on normal and tumor cell lines. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:157-62.|[3]Ediriweera MK, Moon JY, Nguyen YT, Cho SK. 10-Gingerol Targets Lipid Rafts Associated PI3K/Akt Signaling in Radio-Resistant Triple Negative Breast Cancer Cells. Molecules. 2020;25 (14) :3164. |[4]Zhang F, et al. Therapeutic Effects of 6-Gingerol, 8-Gingerol, and 10-Gingerol on Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Rats. Phytother Res. 2017 Sep;31 (9) :1427-1432.|[5]Deng B, et al. 10-Gingerol, a natural AMPK agonist, suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. Food Funct. 2022 Mar 21;13 (6) :3234-3246.