Q8
Q8, an effective antiangiogenic drug, is a CysLt1 antagonist (IC50 of 4.9 μM) . Q8 is sufficient to reduce cellular levels of NF-κB and calpain-2 and secreted levels of the proangiogenic proteins intercellular adhesion molecule-1, vascular cell adhesion protein-1, and VEGF[1].
Product Specifications
CAS Number
1541762-55-3
UNSPSC
12352005
Target
Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/q8.html
Smiles
OC1=CC=C(O)C=C1/C=C/C2=NC3=CC=CC=C3C=C2.Cl
Molecular Formula
C17H14ClNO2
Molecular Weight
299.75
References & Citations
[1]Clare T Butler, et al. A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF) -independent Angiogenesis and Exerts an Additive Antiangiogenic Response with Bevacizumab. J Biol Chem. 2017 Mar 3;292 (9) :3552-3567.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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