GSK737
GSK737 is a BRD4 BD1 and BD2 inhibitor, with pIC50 values of 5.3 and 7.3 respectively. GSK737 has low clearance and good solubility and permeability in rat[1].
Product Specifications
CAS Number
[2748687-95-6]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk737.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H](C1=CC=CC=N1)OC2=C(C3=CN(C)N=N3)C=C(C=C2)C(NC4CC4)=O
Molecular Formula
C20H21N5O2
Molecular Weight
363.41
References & Citations
[1]Aylott HE, et al. Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors. J Med Chem. 2021 Mar 25;64 (6) :3249-3281.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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