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Diphenhydramine (hydrochloride)

Product Specifications

UNSPSC Description

Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB)[1][2].

Target Antigen

Apoptosis; Bacterial; Endogenous Metabolite; Histamine Receptor

Type

Reference compound

Related Pathways

Anti-infection;Apoptosis;GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/Diphenhydramine-hydrochloride.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)

Smiles

CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl

Molecular Weight

291.82

References & Citations

[1]Simons FE. H1-receptor antagonists. Comparative tolerability and safety. Drug Saf. 1994;10(5):350-380.|[2]Sadiq MW, et al. Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo. J Pharm Sci. 2011;100(9):3912-3923.|[3]Hamano H, et al. Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity. Kidney Int. 2021 Apr;99(4):885-899.|[4]Jangi SM, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14(7-8):363-72.|[5]Zhang R, Chen M, Yu L, et al. Anticancer activity of diphenhydramine against pancreatic cancer by stimulating cell cycle arrest, apoptosis, and modulation of PI3K/Akt/mTOR pathway[J]. Cell proliferation, 2021, 69: 5.Cell Rep Methods. 2023 Oct 23;3(10):100599.|Cell Rep. 2022 Nov 8;41(6):111615.|Chemosphere. 2019 Jun;225:378-387. |Pharmacol Res Perspect. 2021 Oct;9(5):e00879.|Acta Pharmacol Sin.2024 May 24.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-B0303A/Diphenhydramine-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-B0303A/Diphenhydramine-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

Launched

CAS Number

147-24-0

Available Sizes

Curated Selection

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