Diphenhydramine (hydrochloride)

Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) [1][2].

Product Specifications

CAS Number

[147-24-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bacterial; Endogenous Metabolite; Histamine Receptor

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/Diphenhydramine-hydrochloride.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl

Molecular Formula

C17H22ClNO

Molecular Weight

291.82

Precautions

H302, H315, H319, H335

References & Citations

[1]Simons FE. H1-receptor antagonists. Comparative tolerability and safety. Drug Saf. 1994;10 (5) :350-380.|[2]Sadiq MW, et al. Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo. J Pharm Sci. 2011;100 (9) :3912-3923.|[3]Hamano H, et al. Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity. Kidney Int. 2021 Apr;99 (4) :885-899.|[4]Jangi SM, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14 (7-8) :363-72.|[5]Zhang R, Chen M, Yu L, et al. Anticancer activity of diphenhydramine against pancreatic cancer by stimulating cell cycle arrest, apoptosis, and modulation of PI3K/Akt/mTOR pathway[J]. Cell proliferation, 2021, 69: 5.