UK-78282 (hydrochloride)

UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil[1].

Product Specifications

CAS Number

[136647-02-4]

UNSPSC

12352005

Hazard Statement

H319, H410

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/uk-78282-hydrochloride.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=C(CCCN2CCC(COC(C3=CC=CC=C3)C4=CC=CC=C4)CC2)C=C1.[H]Cl

Molecular Formula

C29H36ClNO2

Molecular Weight

466.05

Precautions

H319, H410

References & Citations

[1]D C Hanson, et al. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr;126 (8) :1707-16