Tie2 kinase inhibitor 3
Tie2 kinase inhibitor 3 (compound 63) is a potent Tie-2 kinase inhibitor with good oral activity (IC50=30 nM) . Tie2 kinase inhibitor 3 inhibits phosphorylation and signaling of Tie-2 by competing with the ATP binding site of Tie-2 kinase. This inhibition affects the stability and maturity of blood vessels, which has an impact on tumor angiogenesis. Tie2 kinase inhibitor 3 can be used to restrict tumor growth and regulate angiogenesis[1].
Product Specifications
CAS Number
870225-11-9
UNSPSC
12352005
Target
Tie
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tie2-kinase-inhibitor-3.html
Smiles
O=C(C1=CC(OC2=C(C3=NC(NC)=NC=N3)C=CC=N2)=CC=C1F)NC4=CC(C(F)(F)F)=CC=C4N(CCCN(C)C)C
Molecular Formula
C29H30F4N8O2
Molecular Weight
598.59
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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