Pyrantel (pamoate)

Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR) . Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].

Product Specifications

CAS Number

[22204-24-6]

Product Name Alternative

Pyrantel embonate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; nAChR; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Pyrantel-pamoate.html

Purity

99.97

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(O)C(CC2=C3C=CC=CC3=CC(C(O)=O)=C2O)=C4C=CC=CC4=C1)O.CN5CCCN=C5/C=C/C6=CC=CS6

Molecular Formula

C34H30N2O6S

Molecular Weight

594.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Martin RJ, et, al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol. 2004 Aug;34 (9) :1083-90.|[2]Tritten L, et, al. In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS Negl Trop Dis. 2011 Dec;5 (12) :e1457.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Eur J Med Chem. 2024 Dec 5:279:116842.|Clin Transl Med. 2025 Apr;15 (4) :e70311.|Curr Eye Res. 2025 Jun 24:1-9.|Int Immunopharmacol. 2024 Jul 23:139:112720.

Available Sizes

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