Tumor Necrosis Factor-alpha/TNFSF2 (Human)

<strong>Tumor Necrosis Factor-alpha/TNFSF2 (Human)</strong>_x000D_ <strong>Catalog number:</strong> B2010326_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Tumor Necrosis Factor-alpha/TNFSF2 (Human) expressed in P. pastoris. This protein acts as a strong pro-inflammatory cytokine with tumor cell targeting capability and with low toxicity levels towards healthy cells._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuTNF-α/TNFSF2; TNF-alpha; Cachectin; DIF; TNFA; Differentiation-inducing factor_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Juuti-Uusitalo K, Klunder LJ, Sjollema KA, Mackovicova K, Ohgaki R, Hoekstra_x000D_ D, Dekker J, van Ijzendoorn SC. Differential effects of TNF (TNFSF2) and IFN-γ_x000D_ on intestinal epithelial cell morphogenesis and barrier function in three-_x000D_ dimensional culture. PLoS One. 2011;6(8):e22967._x000D_ _x000D_ 2: Chen H, Zhang X, Liao N, Ji Y, Mi L, Gan Y, Su Y, Wen F. Identification of_x000D_ NLRP3 Inflammation-Related Gene Promoter Hypomethylation in Diabetic_x000D_ Retinopathy. Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):12._x000D_ _x000D_ 3: Heimroth RD, Casadei E, Salinas I. Molecular Drivers of Lymphocyte_x000D_ Organization in Vertebrate Mucosal Surfaces: Revisiting the TNF Superfamily_x000D_ Hypothesis. J Immunol. 2020 May 15;204(10):2697-2711._x000D_ _x000D_ 4: Kirkpatrick A, Bidwell J, van den Brule AJ, Meijer CJ, Pawade J, Glew S._x000D_ TNFalpha polymorphism frequencies in HPV-associated cervical dysplasia. Gynecol_x000D_ Oncol. 2004 Feb;92(2):675-9._x000D_ _x000D_ 5: Mitsuhashi M, Targan SR. Ex vivo simulation of IgG Fc and T-cell receptor_x000D_ functions: an application to inflammatory bowel disease. Inflamm Bowel Dis. 2008_x000D_ Aug;14(8):1061-7._x000D_ _x000D_ 6: Strålberg F, Kassem A, Kasprzykowski F, Abrahamson M, Grubb A, Lindholm C,_x000D_ Lerner UH. Inhibition of lipopolysaccharide-induced osteoclast formation and_x000D_ bone resorption in vitro and in vivo by cysteine proteinase inhibitors. J Leukoc_x000D_ Biol. 2017 May;101(5):1233-1243._x000D_ _x000D_ 7: Kato Y, Mitsuhashi M. [Prediction of WT1/MUC1 peptide dendritic cell therapy_x000D_ responders by quantification of ex vivo induced mRNA in whole blood]. Gan To_x000D_ Kagaku Ryoho. 2012 Nov;39(12):1803-5._x000D_ _x000D_ 8: Wei SC, Ni YH, Yang HI, Su YN, Chang MC, Chang YT, Shieh MJ, Wang CY, Wong_x000D_ JM. A hospital-based study of clinical and genetic features of Crohn's disease._x000D_ J Formos Med Assoc. 2011 Sep;110(9):600-6._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/21422709/">9: Tovar V, Ogura M, Kobayashi A, Kimura S, Saito K, Kainuma M, Yohda M,_x000D_ Hasegawa S, Mitsuhashi M. A dried tofu-supplemented diet affects mRNA expression_x000D_ of inflammatory cytokines in human blood. J Nutr Sci Vitaminol (Tokyo)._x000D_ 2010;56(6):396-410. </a>_x000D_ _x000D_ <strong>Products Related to Tumor Necrosis Factor-alpha/TNFSF2 (Human) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>