MonoHER
MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner[1].
Product Specifications
CAS Number
23869-24-1
Product Name Alternative
7-Monohydroxyethylrutoside
UNSPSC
12352005
Target
Carbonyl Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/monoher.html
Purity
97.02
Solubility
10 mM in DMSO
Smiles
O=C1C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)O2)O)O)O)=C(C4=CC=C(O)C(O)=C4)OC5=CC(OCCO)=CC(O)=C15
Molecular Formula
C29H34O17
Molecular Weight
654.57
References & Citations
[1]Gonzalez-Covarrubias V, et al. Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER) . Pharm Res. 2008 Jul;25 (7) :1730-4.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBR1
Available Sizes
Frequently Asked Questions
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