MonoHER

MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner[1].

Product Specifications

CAS Number

[23869-24-1]

Product Name Alternative

7-Monohydroxyethylrutoside

UNSPSC

12352005

Target

Carbonyl Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/monoher.html

Purity

97.02

Solubility

10 mM in DMSO

Smiles

O=C1C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)O2)O)O)O)=C(C4=CC=C(O)C(O)=C4)OC5=CC(OCCO)=CC(O)=C15

Molecular Formula

C29H34O17

Molecular Weight

654.57

References & Citations

[1]Gonzalez-Covarrubias V, et al. Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER) . Pharm Res. 2008 Jul;25 (7) :1730-4.