Carnosine conjugated hyalyronate
Carnosine conjugated hyalyronate is a hyaluronic acid derivative functionalized with the dipeptide carnosine (Carnosine, Car) and has the ability to resist Aβ amyloid aggregation. Carnosine conjugated hyalyronate dissolves amyloid fibrils and reduces Aβ-induced toxicity in vitro. The effectiveness of Carnosine conjugated hyalyronate against amyloid aggregation is directly proportional to the Carnosine loading[1].
Product Specifications
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/carnosine-conjugated-hyalyronate.html
Purity
90.0
Solubility
H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
Molecular Weight
600000 (Average)
References & Citations
[1]Greco V, et al. Hyaluronan-carnosine conjugates inhibit Aβ aggregation and toxicity. Sci Rep. 2020 Sep 29;10 (1) :15998.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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