Carnosine conjugated hyalyronate
Product Specifications
UNSPSC Description
Carnosine conjugated hyalyronate is a hyaluronic acid derivative functionalized with the dipeptide carnosine (Carnosine, Car) and has the ability to resist Aβ amyloid aggregation. Carnosine conjugated hyalyronate dissolves amyloid fibrils and reduces Aβ-induced toxicity in vitro. The effectiveness of Carnosine conjugated hyalyronate against amyloid aggregation is directly proportional to the Carnosine loading[1].
Target Antigen
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/carnosine-conjugated-hyalyronate.html
Smiles
OC[C@H]1O[C@@H](OC)[C@H](NC(C)=O)[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O[C@H]3[C@H](NC(C)=O)[C@@H](O[C@H]4[C@H](O)[C@H](O)[C@H](OC)[C@@H](C(NCCC(N[C@H](C(O[Na])=O)CC5=CNC=N5)=O)=O)O4)[C@H](O)[C@@H](CO)O3)[C@@H](C([O-])=O)O2)[C@@H]1O.[Na+]
Molecular Weight
600000(Average)
References & Citations
[1]Greco V, et al. Hyaluronan-carnosine conjugates inhibit Aβ aggregation and toxicity. Sci Rep. 2020 Sep 29;10(1):15998.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148495/Carnosine-conjugated-hyalyronate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148495/Carnosine-conjugated-hyalyronate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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