Jagged-1 (188-204) (TFA)

Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells[1][2][3].

Product Specifications

UNSPSC

12352209

Target

Notch

Type

Peptides

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jagged-1-188-204-tfa.html

Purity

99.89

Solubility

DMSO : 50 mg/mL|H2O : ≥ 25 mg/mL

Smiles

O=C(O)C(F)(F)F.O=C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(N[C@@H](CS)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N6[C@@H](CCC6)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N

Molecular Formula

C95H128F3N25O28S3

Molecular Weight

2221.42

References & Citations

[1]Jundt F, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood. 2004 May 1;103 (9) :3511-5.|[2]Nickoloff BJ, et al. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002 Aug;9 (8) :842-55.|[3]Yamamura H, et al. Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca (2+) entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2014 May 1;306 (9) :C871-8.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Citation 01

BMC Nephrol. 2025 Apr 17;26 (1) :196.|Exp Cell Res. 2025 Oct 1;452 (2) :114711.|FASEB J. 2025 Jan 31;39 (2) :e70364.|Heliyon. 2024 Jun 27;10 (13) :e33803.|Inflammation. 2022 Dec;45 (6) :2449-2464.|Int J Mol Med. 2025 May;55 (5) :77.|Int J Radiat Oncol Biol Phys. 2024 Sep 10:S0360-3016 (24) 03330-3.|J Appl Toxicol. 2023 Nov;43 (11) :1702-1718.|J Biochem Mol Toxicol. 2025 Feb;39 (2) :e70129.|Pathol Res Pract. 2025 Sep 8:275:156217.|Research Square Preprint. 2022 May.|World J Gastrointest Oncol. 2024 Nov 15;16 (11) :4456-4467.|Cell Prolif. 2023 Aug;56 (8) :e13427.|Int J Mol Sci. 2025 Jan 1;26 (1) :307.|Life Sci. 2023 Sep 1:328:121921.