D-Arginine

D-arginine (H-D-Arg-OH) is the D-isomer of arginine. Arginine is an α-amino acid that is used in the biosynthesis of proteins. D-Arginine is an inactive form of L-arginine. D-arginine can be used in myeloma and neurological disease research[1][2][3][4][5][6][7][8].[1].

Product Specifications

CAS Number

[157-06-2]

Product Name Alternative

H-D-Arg-OH

UNSPSC

12352211

Hazard Statement

H319

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d-arginine.html

Purity

98.0

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

N[C@H](CCCNC(N)=N)C(O)=O

Molecular Formula

C6H14N4O2

Molecular Weight

174.20

Precautions

H319

References & Citations

[1]Eduardo Navarro , et al. Toxicological and Pharmacological Effects of D-arginine. Basic Clin Pharmacol Toxicol. 2005 Sep;97 (3) :149-54.|[2]Chin-Dusting JP, et al. Effects of in vivo and in vitro L-arginine supplementation on healthy human vessels. J Cardiovasc Pharmacol. 1996 Jul;28 (1) :158-66. |[3]Du C, et al. D-arginine-loaded metal-organic frameworks nanoparticles sensitize osteosarcoma to radiotherapy. Biomaterials. 2021 Feb;269:120642.|[4]Ma Y, et al. Direct cytosolic delivery of cargoes in vivo by a chimera consisting of D- and L-arginine residues. J Control Release. 2012 Sep 10;162 (2) :286-94.|[5]Navarro E, et al. Toxicological and pharmacological effects of D-arginine. Basic Clin Pharmacol Toxicol. 2005 Sep;97 (3) :149-54.|[6]Kim DR, et al. The effects of a comparatively higher dose of 1000 mg/kg/d of oral L- or D-arginine on the L-arginine metabolic pathways in male Sprague-Dawley rats. PLoS One. 2023 Aug 1;18 (8) :e0289476.|[7]Kawabata A, et al. L-leucyl-L-arginine, naltrindole and D-arginine block antinociception elicited by L-arginine in mice with carrageenin-induced hyperalgesia. Br J Pharmacol. 1992 Dec;107 (4) :1096-101.|[8]Zakaria ZA, et al. The effects of L-arginine, D-arginine, L-name and methylene blue on channa striatus-induced peripheral antinociception in mice. J Pharm Pharm Sci. 2005 Aug 3;8 (2) :199-206.