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CSN5-IN-1

CSN5-IN-1 (compound Ac-11) is an inhibitor of CSN5, with IC50 values of 12.56 μM and 19 μM as measured by FP assay and fluorescence assay, respectively. CSN5-IN-1 can also downregulate the expression of PD-L1 and upregulate the expression of NEDD8-Cul1 in cells[1].

Product Specifications

UNSPSC

12352005

Target

E1/E2/E3 Enzyme; PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/csn5-in-1.html

Smiles

O=C(C1=C(C(C)CC2=CC=C(C(C)(C)C)C=C2)SC(N)=N1)O

Molecular Formula

C17H22N2O2S

Molecular Weight

318.43

References & Citations

[1]Discovering New Metallo-Deubiquitinase CSN5 Inhibitors by a Non-Catalytic Activity Assay Platform

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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