CSN5-IN-1
CSN5-IN-1 (compound Ac-11) is an inhibitor of CSN5, with IC50 values of 12.56 μM and 19 μM as measured by FP assay and fluorescence assay, respectively. CSN5-IN-1 can also downregulate the expression of PD-L1 and upregulate the expression of NEDD8-Cul1 in cells[1].
Product Specifications
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/csn5-in-1.html
Smiles
O=C(C1=C(C(C)CC2=CC=C(C(C)(C)C)C=C2)SC(N)=N1)O
Molecular Formula
C17H22N2O2S
Molecular Weight
318.43
References & Citations
[1]Discovering New Metallo-Deubiquitinase CSN5 Inhibitors by a Non-Catalytic Activity Assay Platform
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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