Tirilazad (mesylate hydrate)
Product Specifications
UNSPSC Description
Tirilazad mesylate hydrate is the hydrate form of Tirilazad mesylate (HY-122070). Tirilazad mesylate is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad mesylate can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad mesylate has antiviral activities against nCoV. Tirilazad mesylate is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research[1][2][3].
Target Antigen
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tirilazad-mesylate-hydrate.html
Solubility
10 mM in DMSO
Smiles
CS(=O)(O)=O.C[C@@]12[C@](C[C@H]([C@@H]2C(CN3CCN(C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)CC3)=O)C)([H])[C@@]7([H])C([C@@]8(C(CC7)=CC(C=C8)=O)C)=CC1.O
Molecular Weight
738.98
References & Citations
[1]Bath PM, et al. Tirilazad for acute ischaemic stroke. Cochrane Database Syst Rev. 2001;(4):CD002087. |[2]Zhang S, et al. Tirilazad for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2010 Feb 17;(2):CD006778.|[3]Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee. Stroke. 2000 Sep;31(9):2257-65.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122070A/Tirilazad-mesylate-hydrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122070A/
Clinical Information
Phase 3
CAS Number
111793-42-1
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