What is the catalog number for MAGE-1 Antibody?

The catalog number for MAGE-1 Antibody is orb749658.

What sizes are available for MAGE-1 Antibody?

MAGE-1 Antibody is available in the following size(s): 20 µg, 100 µg.

How many pack sizes does MAGE-1 Antibody come in?

MAGE-1 Antibody is available in 2 different pack sizes.

Is MAGE-1 Antibody in stock?

MAGE-1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

MAGE-1 Antibody

Recognizes a protein of 42-46kDa, identified as MAGE-1. This mAb does not cross-react with other members of MAGE-family. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL) . The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs) . Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

Product Specifications

UniProt

P43355

Reactivity

Human

Immunogen

Recombinant human MAGEA1 protein was used as the immunogen for the MAGE-1 antibody.

Clonality

Monoclonal

Clone

MZ2E/838

Conjugation

Unconjugated

Field of Research

Epigenetics

Purification

Protein G affinity chromatography

Dilution

Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the MAGE-1 antibody should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.