Oxfenicine

Oxfenicine (L-p-Hydroxyphenylglycine) is an orally active carnitine palmitoyltransferase-1 inhibitor. Oxfenicine inhibits the oxidation of fatty acids in the heart, protecting cardiac tissue from necrotic damage during ischemia, and also has an inhibitory effect on cardiac tissue apoptosis. In addition, Oxfenicine promotes lipolysis in a high-fat diet rat model. Oxfenicine can be used in the study of cardiovascular and metabolic diseases[1][2][3][4][5].

Product Specifications

CAS Number

[32462-30-9]

Product Name Alternative

L-p-Hydroxyphenylglycine; 4-Hydroxy-L-phenylglycine; UK 25842

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Acyltransferase; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/h-phg-4-oh-oh.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : < 1 mg/mL (ultrasonic) |H2O : 4.55 mg/mL (ultrasonic)

Smiles

O=C([C@H](C1=CC=C(C=C1)O)N)O

Molecular Formula

C8H9NO3

Molecular Weight

167.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Stephens TW, et, al. Two mechanisms produce tissue-specific inhibition of fatty acid oxidation by oxfenicine. Biochem J. 1985 Apr 15;227 (2) :651-60.|[2]Greaves P, et, al. Cardiac hypertrophy in the dog and rat induced by oxfenicine, an agent which modifies muscle metabolism. Arch Toxicol Suppl. 1984;7:488-93.|[3]Kennedy JA, et al. Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. J Cardiovasc Pharmacol. 2000 Dec;36 (6) :794-801.|[4]Sepa-Kishi DM, et al. Antilipolytic and antilipogenic effects of the CPT-1b inhibitor oxfenicine in the white adipose tissue of rats. Am J Physiol Regul Integr Comp Physiol. 2016 Oct 1;311 (4) :R779-R787.|[5]Kong JY, et al. Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin. Am J Physiol Heart Circ Physiol. 2002 Feb;282 (2) :H717-25.