MK 436
MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America[1][2].
Product Specifications
CAS Number
[33450-08-7]
Product Name Alternative
MK-0436
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mk-436.html
Smiles
O=[N+](C1=CN=C(C2=NOC3CCCCC23)N1C)[O-]
Molecular Formula
C11H14N4O3
Molecular Weight
250.25
References & Citations
[1]VandenHeuvel, et al. Identification of canine urinary metabolites of the antiprotozoal agent 3a, 4, 5, 6, 7, 7a-hexahydro-3- (1-methyl-5-nitro-1H-imidazol-2-yl) -1, 2-benzisoxazole. Journal of pharmaceutical sciences 69.11 (1980) : 1288-1292.|[2]Jennings, et al. Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement. Transactions of the Royal Society of Tropical Medicine and Hygiene 77.5 (1983) : 693-698.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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