MK 436

MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America[1][2].

Product Specifications

CAS Number

[33450-08-7]

Product Name Alternative

MK-0436

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mk-436.html

Smiles

O=[N+](C1=CN=C(C2=NOC3CCCCC23)N1C)[O-]

Molecular Formula

C11H14N4O3

Molecular Weight

250.25

References & Citations

[1]VandenHeuvel, et al. Identification of canine urinary metabolites of the antiprotozoal agent 3a, 4, 5, 6, 7, 7a-hexahydro-3- (1-methyl-5-nitro-1H-imidazol-2-yl) -1, 2-benzisoxazole. Journal of pharmaceutical sciences 69.11 (1980) : 1288-1292.|[2]Jennings, et al. Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement. Transactions of the Royal Society of Tropical Medicine and Hygiene 77.5 (1983) : 693-698.