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UH15-38

UH15-38 is a potent RIPK3 inhibitor with an IC50 value of 20 nM. UH15-38 blocks IAV (influenza A virus) -activated necroptosis. UH15-38 dampens IAV-induced lung injury[1].

Product Specifications

CAS Number

2540881-21-6

UNSPSC

12352005

Target

Influenza Virus; Necroptosis; RIP kinase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/uh15-38.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1CCN(CC1)C2=CC(NC3=NC=C4C=C(C(N(C4=C3)C)=O)C5=CC(O)=CC=C5)=CC=C2

Molecular Formula

C26H27N5O2

Molecular Weight

441.52

References & Citations

[1]Gautam A, et al. Necroptosis blockade prevents lung injury in severe influenza. Nature. 2024 Apr;628 (8009) :835-843.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

RIPK3

Available Sizes

Frequently Asked Questions

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