UH15-38
UH15-38 is a potent RIPK3 inhibitor with an IC50 value of 20 nM. UH15-38 blocks IAV (influenza A virus) -activated necroptosis. UH15-38 dampens IAV-induced lung injury[1].
Product Specifications
CAS Number
2540881-21-6
UNSPSC
12352005
Target
Influenza Virus; Necroptosis; RIP kinase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/uh15-38.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1CCN(CC1)C2=CC(NC3=NC=C4C=C(C(N(C4=C3)C)=O)C5=CC(O)=CC=C5)=CC=C2
Molecular Formula
C26H27N5O2
Molecular Weight
441.52
References & Citations
[1]Gautam A, et al. Necroptosis blockade prevents lung injury in severe influenza. Nature. 2024 Apr;628 (8009) :835-843.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK3
Available Sizes
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