ICRT-5

ICRT-5 is a β-catenin-regulated transcription (CRT) inhibitor. iCRT-5 can block Wnt/β-catenin reporter activity and down regulate β-catenin expression. iCRT-5 can be used for the research of multiple myeloma[1][2].

Product Specifications

CAS Number

[18623-44-4]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Wnt; β-catenin

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/icrt-5.html

Purity

99.1

Solubility

DMSO : 36 mg/mL (ultrasonic; warming)

Smiles

O=C(O)CCCN(C/1=O)C(SC1=C/C2=CC=C(OC)C(OC)=C2)=S

Molecular Formula

C16H17NO5S2

Molecular Weight

367.44

Precautions

H302, H312, H332

References & Citations

[1]Käfer R, et, al. Inhibitors of β-catenin affect the immuno-phenotype and functions of dendritic cells in an inhibitor-specific manner. Int Immunopharmacol. 2016 Mar;32:118-124.|[2]Narayanan BA, et, al. Antagonistic effect of small-molecule inhibitors of Wnt/β-catenin in multiple myeloma. Anticancer Res. 2012 Nov;32 (11) :4697-707.