L1CAM Antibody
This antibody recognizes a cell surface protein of 220-240kDa, identified as L1CAM (L1 cell adhesion molecule) . The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius) ; 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs) ; and 3) SPG1 (spastic paraplegia) . L1CAM also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. antibody to L1CAM is useful in the identification of primitive neuroectodermal tumors. The antibody binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.
Product Specifications
UniProt
P32004
Reactivity
Human
Immunogen
A homogenous suspension of 16 week human fetal brain was used as the immunogen for this L1CAM antibody.
Clonality
Monoclonal
Clone
UJ127
Conjugation
Unconjugated
Field of Research
Neuroscience
Purification
Protein G affinity chromatography
Dilution
ELISA (order BSA/sodium azide-free format for coating)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Tested Applications
ELISA
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa
Available Sizes
Frequently Asked Questions
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