GRK2 Inhibitor 2
Product Specifications
UNSPSC Description
GRK2 Inhibitor 2 is an orally active and selective G protein-coupled receptor kinase 2 (GRK) inhibitor with an IC50 of 19 nM. GRK2 Inhibitor 2 also inhibits Aurora-A with an IC50 of 137 nM. GRK2 Inhibitor 2 can be used in the study of congestive heart failure (HF)[1].
Target Antigen
Aurora Kinase; G Protein-coupled Receptor Kinase (GRK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/grk2-inhibitor-2.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C=NN1CC3=CC(OC)=CC=C3)C=CC(C4=CNN=C4)=C2
Molecular Weight
332.36
References & Citations
[1]Xu G, et al. Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127602.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156863/GRK2-Inhibitor-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156863/GRK2-Inhibitor-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2592436-21-8
Available Sizes
Curated Selection
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