GRK2 Inhibitor 2
GRK2 Inhibitor 2 is an orally active and selective G protein-coupled receptor kinase 2 (GRK) inhibitor with an IC50 of 19 nM. GRK2 Inhibitor 2 also inhibits Aurora-A with an IC50 of 137 nM. GRK2 Inhibitor 2 can be used in the study of congestive heart failure (HF) [1].
Product Specifications
CAS Number
[2592436-21-8]
UNSPSC
12352005
Target
Aurora Kinase; G Protein-coupled Receptor Kinase (GRK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/grk2-inhibitor-2.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C=NN1CC3=CC(OC)=CC=C3)C=CC(C4=CNN=C4)=C2
Molecular Formula
C19H16N4O2
Molecular Weight
332.36
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; GRK2
Available Sizes
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