CLEC4E Antibody
CLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin), is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria), and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130kDa), a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRγ, and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.
Product Specifications
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant protein fragment from the C-terminal portion of human CLEC4E was used as the immunogen for this antibody.
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein A affinity chromatography
Dilution
Western blot: 2-5ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Provided assay concentrations are suggestions only, CLEC4E antibody titration may be required for optimal results.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.5 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Rabbit IgG
Available Sizes
Frequently Asked Questions
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