(Rac) -BIO8898
(Rac) -BIO8898 is a CD40-CD154 co-stimulatory interaction inhibitor. (Rac) -BIO8898 inhibits CD154 binding to CD40-Ig with an IC50 of 25 μM[1].
Product Specifications
CAS Number
[402564-79-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rac-bio8898.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C(NC(C1=NC(C(N2C(CN3CCCC3)CCC2)=O)=CC(C4=CC(C(NCC5=CC(C6=CC=CC=C6)=CC=C5)=O)=NC(C(N7C(CN8CCCC8)CCC7)=O)=C4)=C1)=O)C9CCCCC9
Molecular Formula
C53H64N8O6
Molecular Weight
909.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Laura F Silvian, et al. Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism. ACS Chem Biol. 2011 Jun 17;6 (6) :636-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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