S 18986

S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests[1][2].

Product Specifications

CAS Number

[175340-20-2]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-18986.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=S1(C2=CC=CC=C2N3[C@@](CCC3)([H])N1)=O

Molecular Formula

C10H12N2O2S

Molecular Weight

224.28

References & Citations

[1]Bernard K, et al. DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptorspharmacological profile of a novel cognitive enhancer. CNS Neurosci Ther. 2010 Oct;16 (5) :e193-212.|[2]Bourasset F, et al. Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [ (S) -2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat. Drug Metab Dispos. 2005 Aug;33 (8) :1137-43.