Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SU6656

SU6656 is a Src family kinases inhibitor with IC50s of 280, 20, 130, 170 nM for Src, Yes, Lyn, and Fyn, respectively. SU6656 inhibits FAK phosphorylation at Y576/577, Y925, Y861 sites. SU6656 also inhibits p-AKT.

Product Specifications

CAS Number

330161-87-0

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; FAK; Src

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SU6656.html

Purity

99.01

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=S(C1=CC2=C(NC(/C2=C\C(N3)=CC4=C3CCCC4)=O)C=C1)(N(C)C)=O

Molecular Formula

C19H21N3O3S

Molecular Weight

371.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Blake RA, et al. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol. 2000 Dec;20 (23) :9018-27.|[2]Veracini L, et al. Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas. Oncotarget. 2014 Dec 26.|[3]Wu ML, et al. Divergent signaling pathways cooperatively regulate TGFβ induction of cysteine-rich protein 2 in vascular smooth muscle cells. Cell Commun Signal. 2014 Mar 28;12:22.|[4]Ondrusová L, et al. Inhibition of mTORC1 by SU6656, the selective Src kinase inhibitor, is not accompanied by activation of Akt/PKB signalling in melanoma cells. Folia Biol (Praha) . 2013;59 (4) :162-7.|[5]Kumar A, et al. Pharmacological investigations on possible role of Src kinases in neuroprotective mechanism of ischemic postconditioning in mice. Int J Neurosci. 2014 Oct;124 (10) :777-86.|[6]Liu XF, et al. Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors. Mol Cancer Ther. 2014 Jan;13 (1) :82-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Chromogranin B Recombinant Rabbit Monoclonal Antibody [JE31-72]
HA721398 100 µL

Chromogranin B Recombinant Rabbit Monoclonal Antibody [JE31-72]

Sign In for Pricing
View Details
2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide
TRC-H809740-10MG 10 mg

2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide

Sign In for Pricing
View Details
Mouse CFB (Complement Factor B) ELISA Kit
E-EL-M0334-01 24 Tests

Mouse CFB (Complement Factor B) ELISA Kit

Sign In for Pricing
View Details
Mouse CFB (Complement Factor B) ELISA Kit
E-EL-M0334-02 48 Tests

Mouse CFB (Complement Factor B) ELISA Kit

Sign In for Pricing
View Details
Mouse CFB (Complement Factor B) ELISA Kit
E-EL-M0334-03 96 Tests

Mouse CFB (Complement Factor B) ELISA Kit

Sign In for Pricing
View Details
ENGASE (NM_001042573) Human Recombinant Protein
TP311494L 1 mg

ENGASE (NM_001042573) Human Recombinant Protein

Sign In for Pricing
View Details