Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SU6656

SU6656 is a Src family kinases inhibitor with IC50s of 280, 20, 130, 170 nM for Src, Yes, Lyn, and Fyn, respectively. SU6656 inhibits FAK phosphorylation at Y576/577, Y925, Y861 sites. SU6656 also inhibits p-AKT.

Product Specifications

CAS Number

330161-87-0

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; FAK; Src

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SU6656.html

Purity

99.01

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=S(C1=CC2=C(NC(/C2=C\C(N3)=CC4=C3CCCC4)=O)C=C1)(N(C)C)=O

Molecular Formula

C19H21N3O3S

Molecular Weight

371.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Blake RA, et al. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol. 2000 Dec;20 (23) :9018-27.|[2]Veracini L, et al. Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas. Oncotarget. 2014 Dec 26.|[3]Wu ML, et al. Divergent signaling pathways cooperatively regulate TGFβ induction of cysteine-rich protein 2 in vascular smooth muscle cells. Cell Commun Signal. 2014 Mar 28;12:22.|[4]Ondrusová L, et al. Inhibition of mTORC1 by SU6656, the selective Src kinase inhibitor, is not accompanied by activation of Akt/PKB signalling in melanoma cells. Folia Biol (Praha) . 2013;59 (4) :162-7.|[5]Kumar A, et al. Pharmacological investigations on possible role of Src kinases in neuroprotective mechanism of ischemic postconditioning in mice. Int J Neurosci. 2014 Oct;124 (10) :777-86.|[6]Liu XF, et al. Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors. Mol Cancer Ther. 2014 Jan;13 (1) :82-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Ep-CAM / CD326 (Extracellular Domain) (Epithelial Marker) (EGP40/1373), Biotin conjugate, 0.1mg/mL
BNCB1373-100 1x 100 µL

Ep-CAM / CD326 (Extracellular Domain) (Epithelial Marker) (EGP40/1373), Biotin conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Retinoid X Receptor beta (RXRB) (NM_021976) Human Over-expression Lysate
LC402896 20 µg

Retinoid X Receptor beta (RXRB) (NM_021976) Human Over-expression Lysate

Sign In for Pricing
View Details
Elab Fluor® Violet 450 Anti-Mouse CD5 Antibody[53-7.3]
E-AB-F1185Q-01 50 Tests

Elab Fluor® Violet 450 Anti-Mouse CD5 Antibody[53-7.3]

Sign In for Pricing
View Details
Elab Fluor® Violet 450 Anti-Mouse CD5 Antibody[53-7.3]
E-AB-F1185Q-02 100 Tests

Elab Fluor® Violet 450 Anti-Mouse CD5 Antibody[53-7.3]

Sign In for Pricing
View Details
Elab Fluor® Violet 450 Anti-Mouse CD5 Antibody[53-7.3]
E-AB-F1185Q-03 2x 100 Tests

Elab Fluor® Violet 450 Anti-Mouse CD5 Antibody[53-7.3]

Sign In for Pricing
View Details
Primer Panel
HPP6019C 20x 96 Pre-Arrayed Plates

Primer Panel

Sign In for Pricing
View Details