AMG-222
AMG-222 is a dipeptidyl peptidase IV (DPP-IV) inhibitor that exerts its inhibitory effect by tightly and reversibly binding to DPPIV. AMG 222 binds to human plasma proteins in a saturable and concentration-dependent manner, with a binding rate of 80.8% at 1 nM, while the binding rate decreases to 29.4% at concentrations above 100 nM. AMG-222 can be used in research related to diabetes[1].
Product Specifications
CAS Number
913978-37-7
UNSPSC
12352005
Target
Dipeptidyl Peptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/amg-222.html
Smiles
O=C(C1=CC=C(C(C2=NNN=N2)(C[C@@H](NCC(N3[C@H](C#N)CCC3)=O)C)C4=CC=C(C(N(C)C)=O)C=C4CC5)C5=C1)N(C)C
Molecular Formula
C32H39N9O3
Molecular Weight
597.71
References & Citations
[1]Greene R J, et al. Target-mediated metabolism and target-mediated drug disposition of the DPPIV inhibitor AMG 222[J]. Xenobiotica, 2011, 41 (11) : 945-957.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DPP-4
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