Amauromine

Amauromine is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist with Ki and Kb values of 178 nM and 66.6 nM, respectively[1].

Product Specifications

CAS Number

[88360-87-6]

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Cannabinoid Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/amauromine.html

Solubility

10 mM in DMSO

Smiles

C=CC(C)([C@]12[C@](NC3=CC=CC=C23)([H])N4[C@@](C(N5[C@](C[C@]6(C(C)(C)C=C)[C@@]5([H])NC7=CC=CC=C67)([H])C4=O)=O)([H])C1)C

Molecular Formula

C32H36N4O2

Molecular Weight

508.65

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Elsebai MF, et al. Identification of a Potent and Selective Cannabinoid CB1 Receptor Antagonist from Auxarthron reticulatum. ACS Med Chem Lett. 2011 Sep 17;2 (11) :866-9.