P-fin4

P-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators[1].

Product Specifications

CAS Number

2883747-74-6

UNSPSC

12352209

Target

IGluR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/p-fin4.html

Solubility

10 mM in DMSO

Smiles

N[C@@](CCC(O)=O)(C(NCC(N[C@@](Cc1ccc(O)cc1)(C(N[C@@](CC(N)=O)(C(N[C@@](C(C)C)(C(N[C@H](C(N[C@@](CCC(O)=O)(C(O)=O)[H])=O)CC2=CC=C(C=C2)OP(O)(O)=O)=O)[H])=O)[H])=O)[H])=O)=O)[H]

Molecular Formula

C39H53N8O18P

Molecular Weight

952.85

References & Citations

[1]Szedlacsek HS, et al. Designed Peptide Inhibitors of STEP Phosphatase-GluA2 AMPA Receptor Interaction Enhance the Cognitive Performance in Rats. J Med Chem. 2022;65 (1) :217-233.