20-5,14-HEDE

20-5,14-HEDE (WIT003) is an analog of 20-HETE. 20-5,14-HEDE activates PI3K/Akt signaling pathway, thereby exhibiting anti-apoptotic and cell survival promoting effects. 20-5,14-HEDE is the agonist for 20-HETE that increases intracellular Ca2+ concentrations, thereby enhancing vasoconstriction[1][2].

Product Specifications

CAS Number

[240427-86-5]

Product Name Alternative

WIT003

UNSPSC

12352211

Target

Akt; Apoptosis; Caspase; DNA/RNA Synthesis; PI3K; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/20-5-14-hede.html

Purity

98.34

Solubility

DMSO : ≥ 150 mg/mL

Smiles

OCCCCC/C=C\CCCCCCC/C=C\CCCC(O)=O

Molecular Formula

C20H36O3

Molecular Weight

324.50

References & Citations

[1]Dhanasekaran, et al. "20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells." American Journal of Physiology-Heart and Circulatory Physiology 296.3 (2009) : H777-H786.|[2]Yu M, et al., Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. Eur J Pharmacol. 2004 Feb 23;486 (3) :297-306.