Velpatasvir-13C, d3
Velpatasvir-13C, d3 (GS-5816-13C, d3) is 13C and deuterium labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.16 μM[1][2][3].
Product Specifications
Product Name Alternative
GS-5816-13C, d3
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Cancer; Infection; Inflammation/Immunology
Smiles
O=C(OC)N[C@@H](C(C)C)C(N1[C@@H](C2=NC3=CC=C4C=C5C(OCC6=C5C=CC(C7=CNC([C@H]8N(C([C@H](NC(O[13C]([2H])([2H])[2H])=O)C9=CC=CC=C9)=O)C[C@@H](COC)C8)=N7)=C6)=CC4=C3N2)CC[C@@H]1C)=O
Molecular Formula
C48 13CH51D3N8O8
Molecular Weight
887.01
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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