CamA-IN-1

CamA-IN-1 is a Clostridioides difficile-specific DNA adenine methyltransferase (CamA) inhibitor. CamA-IN-1 has inhibitory for CamA with IC50 and Kd values of 0.4 μM and 0.2 μM, respectively. CamA-IN-1 can be used for the research of Clostridioides difficile infections (CDI) [1].

Product Specifications

CAS Number

[2924055-46-7]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cama-in-1.html

Concentration

10mM

Purity

99.03

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CCC(CCCNC2=C3N=CN([C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)C3=NC=N2)CC1)OC(C)(C)C

Molecular Formula

C23H36N6O6

Molecular Weight

492.57

References & Citations

[1]Jujun Zhou, et al. Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence. J Med Chem. 2023 Jan 12;66 (1) :934-950.