(R, S, R) -ML334
(R, S, R) -ML334 is the isomer of ML334 , and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2].
Product Specifications
CAS Number
1432065-33-2
Product Name Alternative
(R, S, R) -LH601A
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Drug Isomer
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-s-r-ml334.html
Concentration
10mM
Purity
98.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1[C@@H](C(N2[C@@H](CN(C(C3=C4C=CC=C3)=O)C4=O)C5=C(C=CC=C5)CC2)=O)CCCC1)O
Molecular Formula
C26H26N2O5
Molecular Weight
446.50
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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