GW-806742X

GW-806742X is a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, as well as a human and murine necroptosis inhibitor. GW806742X binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and displays anti-necroptosis activity. GW806742X blocks necroptosis and IL-33 release in vitro and reduces eosinophilia in Aspergillus fumigatus extract-induced asthma in vivo, an allergic inflammation model that is highly dependent on IL-33.