Phospho-Chk2 (Thr68) Rabbit APC Conjugate

<strong>Phospho-Chk2 (Thr68) Rabbit APC Conjugate </strong>_x000D_ <strong>Catalog number:</strong> B2018874_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8°C_x000D_ <strong>Keywords:</strong> Serine/threonine-protein kinase Chk2, Cds1 homolog, Hucds2, CHEK2, RAD53_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Hsieh CC, Hsu SH, Lin CY, Liaw HJ, Li TW, Jiang KY, Chiang NJ, Chen SH, Lin BW, Chen PC, Chan RH, Lin PC, Yeh YM, Shen CH. CHK2 activation contributes to the development of oxaliplatin resistance in colorectal cancer Br J Cancer. 2022 Nov;127(9):1615-1628._x000D_ 2: Yan H, Jiang J, Du A, Gao J, Zhang D, Song L. Genistein Enhances Radiosensitivity of Human Hepatocellular Carcinoma Cells by Inducing G2/M Arrest and Apoptosis Radiat Res. 2020 Mar;193(3):286-300._x000D_ 3: Chou SJ, Alawi F. Expression of DNA damage response biomarkers during oral carcinogenesis Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Mar;111(3):346-53._x000D_ 4: Chen Y, Miao ZH, Zhao WM, Ding J. The p53 pathway is synergized by p38 MAPK signaling to mediate 11,11'-dideoxyverticillin-induced G2/M arrest FEBS Lett. 2005 Jul 4;579(17):3683-90._x000D_ 5: Eymin B, Claverie P, Salon C, Leduc C, Col E, Brambilla E, Khochbin S, Gazzeri S. p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress Mol Cell Biol. 2006 Jun;26(11):4339-50._x000D_ 6: Chen WS, Lee YJ, Yu YC, Hsaio CH, Yen JH, Yu SH, Tsai YJ, Chiu SJ. Enhancement of p53-mutant human colorectal cancer cells radiosensitivity by flavonoid fisetin Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1527-35._x000D_ 7: Ouchi M, Ouchi T. Distinct DNA damage determines differential phosphorylation of Chk2 Cancer Biol Ther. 2014;15(12):1700-4._x000D_ 8: Oliva-Trastoy M, Berthonaud V, Chevalier A, Ducrot C, Marsolier-Kergoat MC, Mann C, Leteurtre F. The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase Oncogene. 2007 Mar 1;26(10):1449-58._x000D_ 9: Zhao H, Traganos F, Darzynkiewicz Z. Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase Cytometry A. 2008 Jun;73(6):480-9._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/21722802">10: Darzynkiewicz Z, Traganos F, Zhao H, Halicka HD, Skommer J, Wlodkowic D. Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry Methods Cell Biol. 2011;103:115-47. </a>_x000D_ _x000D_ <strong>Products Related to Phospho-Chk2 (Thr68) Rabbit APC Conjugate can be found at</strong> <a href="https://moleculardepot.com/product-category/Conjugates/"> Conjugates</a>