TCO-PEG3-Glu-Val-Cit-PABC-MMAF

TCO-PEG3-Glu-Val-Cit-PABC-MMAF is a linker-drug conjugate, which is consisted of a click pair TCO, a spacer PEG, a cleavable linker Glu-Val-Cit, a PBAC group and a cytotoxin MMAF (HY-15579) . TCO-PEG3-Glu-Val-Cit-PABC-MMAF can be used for synthesis of dual drug ADC[1].

Product Specifications

CAS Number

[2862795-63-7]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tco-peg3-glu-val-cit-pabc-mmaf.html

Smiles

O=C(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N(CCC1)[C@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC(COCCOCCOCCNC(OC4CC/C=C\CCC4)=O)=O)=O)=O)=O

Molecular Formula

C80H126N12O22

Molecular Weight

1607.92

References & Citations

[1]Yamazaki CM, et al., Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance. Nat Commun. 2021 Jun 10;12 (1) :3528.