PKMYT1-IN-1

PKMYT1-IN-1 (Compound 1) is an inhibitor for membrane-associated tyrosine and threonine kinase (PKMYT1), with an IC50 of 8.8 nM. PKMYT1-IN-1 inhibits proliferation of tumor cell HCC1569 with IC50 of 42 nM[1].

Product Specifications

CAS Number

[3033609-83-2]

UNSPSC

12352005

Target

Wee1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pkmyt1-in-1.html

Purity

99.2400

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C(C)=C1N2C(N)=C3C(NC4=C(C5=NC=NC2=C53)C=CC=C4)=O)O

Molecular Formula

C21H17N5O2

Molecular Weight

371.39

References & Citations

[1]Zhu D, et al., Membrane-associated tyrosine and threonine kinase inhibitor and use thereof. WO2024061343A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PKMYT1

Available Sizes

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