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Dauricine (Standard)

Dauricine (Standard) is the analytical standard of Dauricine. This product is intended for research and analytical applications. Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose-and time-dependent manner in colon cancer[1].

Product Specifications

CAS Number

524-17-4

UNSPSC

12352005

Target

Apoptosis; NF-κB; Oxidative Phosphorylation; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dauricine-standard.html

Smiles

OC1=CC=C(C[C@H]2N(C)CCC3=C2C=C(OC)C(OC)=C3)C=C1OC4=CC=C(C[C@H]5N(C)CCC6=C5C=C(OC)C(OC)=C6)C=C4

Molecular Formula

C38H44N2O6

Molecular Weight

624.77

References & Citations

[1]Yang Z, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225 (1) :266-75.|[2]Chen C, et al. Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease. Front Cell Dev Biol. 2021 Feb 5;8:624339. |[3]Li W, et al. Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation. Food Chem Toxicol. 2018 Nov;121:156-165.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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