Folate-FITC

Folate-FITC (EC-17) is a folate receptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The Folate-FITC maximum excitation and emission wavelengths are 490 nm and 520 nm, respectively[1][2].

Product Specifications

CAS Number

[583037-91-6]

Product Name Alternative

EC-17

UNSPSC

12171500

Target

Fluorescent Dye; Folate Receptor (FR)

Type

Dye Reagents

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/folate-ftic.html

Purity

95.17

Smiles

O=C1OC2(C3=CC=C(O)C=C3OC4=CC(O)=CC=C42)C5=CC=C(NC(NCCNC(CC[C@@H](C(O)=O)NC(C6=CC=C(C=C6)NCC(N=C78)=CNC7=NC(N)=NC8=O)=O)=O)=S)C=C51

Molecular Formula

C42H36N10O10S

Molecular Weight

872.86

References & Citations

[1]Tummers QR, et al. Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17. Oncotarget. 2016 May 31;7 (22) :32144-55.|[2]Patil RA, et al. Fluorescence Labeling of Circulating Tumor Cells with a Folate Receptor-Targeted Molecular Probe for Diffuse In Vivo Flow Cytometry. Mol Imaging Biol. 2020 Oct;22 (5) :1280-1289.